Klaus Mohnike Selected Research

vosoritide

4/2024	Development of a Weight-Band Dosing Approach for Vosoritide in Children with Achondroplasia Using a Population Pharmacokinetic Model.
10/2023	Vosoritide Therapy in Children with Achondroplasia: Early Experience and Practical Considerations for Clinical Practice.
1/2023	Parents' Experience of Administering Vosoritide: A Daily Injectable for Children with Achondroplasia.
12/2022	Growth parameters in children with achondroplasia: A 7-year, prospective, multinational, observational study.
1/2022	Literature review and expert opinion on the impact of achondroplasia on medical complications and health-related quality of life and expectations for long-term impact of vosoritide: a modified Delphi study.
1/2022	Pharmacokinetics and Exposure-Response of Vosoritide in Children with Achondroplasia.
12/2021	Safe and persistent growth-promoting effects of vosoritide in children with achondroplasia: 2-year results from an open-label, phase 3 extension study.
1/2020	Once-daily, subcutaneous vosoritide therapy in children with achondroplasia: a randomised, double-blind, phase 3, placebo-controlled, multicentre trial.

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Klaus Mohnike Research Topics

Disease

13	Achondroplasia 04/2024 - 10/2005
7	Congenital Hyperinsulinism 01/2022 - 03/2008
6	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 04/2022 - 07/2015
2	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 04/2022 - 07/2015
2	Hypoglycemia (Reactive Hypoglycemia) 12/2021 - 05/2010
2	Rickets (Rachitis) 11/2017 - 12/2004
2	Hypertension (High Blood Pressure) 02/2016 - 06/2004
2	Hyperplasia 05/2010 - 02/2002
1	Body Weight (Weight, Body) 04/2024
1	Injection Site Reaction 10/2023
1	Pathologic Constriction (Stenosis) 01/2023
1	Hyperinsulinism (Hyperinsulinemia) 12/2021
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/2020
1	Exocrine Pancreatic Insufficiency 12/2018
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/2018
1	Anastomotic Leak 11/2018
1	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 11/2017
1	Phenylketonurias (Phenylketonuria) 11/2017
1	Joint Diseases (Joint Disease) 08/2017
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 07/2007
1	Ornithine Carbamoyltransferase Deficiency Disease 07/2007
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 05/2005
1	Androgen-Insensitivity Syndrome (Testicular Feminization) 01/2005
1	Disorders of Sex Development (Intersexuality) 01/2005
1	Familial Hypophosphatemia (Phosphate Diabetes) 12/2004
1	Fever (Fevers) 09/2004
1	Appendicitis 09/2004
1	Whooping Cough (Pertussis) 09/2004
1	Erythema 11/2002
1	Cicatrix (Scar) 11/2002
1	Cushing Syndrome 02/2002
1	Pain (Aches) 02/2002

Drug/Important Bio-Agent (IBA)

8	vosoritideIBA 04/2024 - 01/2020
5	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2023 - 01/2021
4	SaltsIBA 04/2022 - 07/2015
4	Glucose (Dextrose)FDA LinkGeneric 02/2011 - 06/2004
3	Hydrocortisone (Cortisol)FDA LinkGeneric 05/2021 - 02/2002
2	MineralocorticoidsIBA 04/2022 - 05/2021
2	GlucocorticoidsIBA 04/2022 - 05/2021
2	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 01/2022 - 12/2021
2	AndrogensIBA 05/2021 - 07/2015
2	Phosphates (Orthophosphate)IBA 01/2020 - 11/2017
2	FludrocortisoneIBA 01/2018 - 02/2016
2	Glucagon (Glukagon)FDA Link 05/2010 - 11/2002
1	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2022
1	Diazoxide (Hyperstat)FDA Link 12/2021
1	CarbohydratesIBA 12/2021
1	pasireotideIBA 12/2021
1	Hormones (Hormone)IBA 04/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2021
1	Mannose (D-Mannose)IBA 01/2020
1	IsomerasesIBA 01/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 02/2019
1	Biomarkers (Surrogate Marker)IBA 11/2018
1	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2018
1	Sodium Chloride FDA LinkGeneric 01/2018
1	Calcitriol (Calcijex)FDA LinkGeneric 11/2017
1	Amino Acids FDA Link 11/2017
1	Vitamin D FDA LinkGeneric 11/2017
1	Aggrecans (Aggrecan)IBA 08/2017
1	EnzymesIBA 07/2015
1	KATP ChannelsIBA 01/2014
1	Levodopa (L Dopa)FDA LinkGeneric 03/2008
1	DystrophinIBA 07/2007
1	cytochrome b245IBA 07/2007
1	GTP Phosphohydrolases (GTPases)IBA 07/2007
1	Growth Hormone (Somatotropin)IBA 10/2005
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 05/2005
1	Insulin-Like Growth Factor I (IGF-1)IBA 05/2005
1	Insulin-Like Growth Factor Binding Protein 3IBA 05/2005
1	Insulin-Like Growth Factor Binding Protein 2IBA 05/2005
1	Insulin-Like PeptidesIBA 05/2005
1	Insulin-Like Growth Factor Binding ProteinsIBA 05/2005
1	Androgen Receptors (Androgen Receptor)IBA 01/2005
1	Peptides (Polypeptides)IBA 12/2004
1	AntipyreticsIBA 09/2004
1	Pertussis VaccineIBA 09/2004
1	VaccinesIBA 09/2004
1	HDL CholesterolIBA 06/2004
1	CholesterolIBA 06/2004
1	Triglycerides (Triacylglycerol)IBA 06/2004
1	LDL CholesterolIBA 06/2004

Therapy/Procedure

7	Therapeutics 04/2024 - 11/2002
4	Pancreatectomy 12/2021 - 11/2002
1	Injections 01/2023
1	Decompression 01/2023
1	Length of Stay 11/2018
1	Secondary Prevention 11/2017
1	Cesarean Section (Caesarean Section) 02/2002
1	Adrenalectomy 02/2002